Subdivision of the Cardiac Nkx2.5 Expression Domain into Myogenic and Nonmyogenic Compartments

Michael Raffin; Li Ming Leong; Melissa S. Rones; Duncan Sparrow; Tim Mohun; Mark Mercola

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Subdivision of the Cardiac Nkx2.5 Expression Domain into Myogenic and Nonmyogenic Compartments

机译：心脏Nkx2.5表达域细分为成肌和非成肌间隔

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Nkx2.5isexpressedinthecardiogenicmesodermofavian,mouse,andamphibianembryos.Tounderstandhowvariouscardiacfateswithinthisdomainareapportioned,wefatemappedthemesodermalXNkx2.5domainofneuraltubestageemXenopus/emembryos.ThelateralportionsoftheXNkx2.5expressiondomainintheneuraltubestageembryo(stage22)formthedorsalmesocardiumandroofofthepericardialcavitywhiletheinterveningventralregionclosestoformthemyocardialtube.XNkx2.5expressionismaintainedthroughouttheperiodofhearttubemorphogenesisanddifferentiationofmyocardial,mesocardial,andpericardialtissues.Aseriesofmicrosurgicalexperimentsshowedthatmyocardialdifferentiationinthelateralportionofthefieldissuppressedduringnormaldevelopmentbysignalsfromtheprospectivemyocardiumandbytissueslocatedmoredorsallyintheembryo,inparticulartheneuraltube.ThesesignalscombinetoblockmyogenesisdownstreamofXNkx2.5andatorabovethelevelofcontractileproteingeneexpression.WeproposethattheentireXNkx2.5/heartfieldistransientlyspecifiedascardiomyogenic.Suppressionofthisprogramredirectslateralcellstoadoptdorsalmesocardialanddorsalpericardialfatesandsubdividesthefieldintodistinctmyogenicandnonmyogeniccompartments./p/div

机译：Nkx2.5isexpressedinthecardiogenicmesodermofavian，鼠标，andamphibianembryos.Tounderstandhowvariouscardiacfateswithinthisdomainareapportioned，wefatemappedthemesodermalXNkx2.5domainofneuraltubestage 爪蟾 embryos.ThelateralportionsoftheXNkx2.5expressiondomainintheneuraltubestageembryo（stage22）formthedorsalmesocardiumandroofofthepericardialcavitywhiletheinterveningventralregionclosestoformthemyocardialtube.XNkx2.5expressionismaintainedthroughouttheperiodofhearttubemorphogenesisanddifferentiationofmyocardial，mesocardial，andpericardialtissues.Aseriesofmicrosurgicalexperimentsshowedthatmyocardialdifferentiationinthelateralportionofthefieldissuppressedduringnormaldevelopmentbysignalsfromtheprospectivemyocardiumandbytissueslocatedmoredorsallyintheembryo，inparticulartheneuraltube.ThesesignalscombinetoblockmyogenesisdownstreamofXNkx2.5andatorabovethelevelofcontractileproteingeneexpression.WeproposethattheentireXNkx2.5 / heartfield暂时指定为致心肌病。间接引导侧细胞进入背心间膜区和背心膜心房并细分该区域的成肌和非成肌室。 展开▼

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《Developmental biology》 |2000年第2期|共页

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Michael Raffin; Li Ming Leong; Melissa S. Rones; Duncan Sparrow; Tim Mohun; Mark Mercola;
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中图分类生物科学;

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专利

1. Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments [J] . Raffin M., Rones MS., Sparrow D., Developmental biology . 2000,第2期

机译：将心脏Nkx2.5表达域细分为成肌和非成肌区室

2. Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene [J] . Sonja Gawlas, Yassemi Capetanaki, Christiane Fuchs, Biology Open . 2016,第2期

机译：Desmin进入心脏干细胞核并通过参与与nkx2.5基因相互作用的转录因子复合物调节Nkx2.5表达Desmin进入心脏干细胞的核并通过参与相互作用的转录因子复合物调节Nkx2.5表达与nkx2.5基因结合的Desmin通过参与与nkx2.5基因相互作用的转录因子复合物进入心脏干细胞核并调节Nkx2.5表达

3. Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene [J] . Sonja Gawlas, Yassemi Capetanaki, Christiane Fuchs, Biology Open . 2016,第2期

机译：Desmin进入心脏干细胞核并通过参与与nkx2.5基因相互作用的转录因子复合物调节Nkx2.5表达Desmin进入心脏干细胞的核并通过参与相互作用的转录因子复合物调节Nkx2.5表达与nkx2.5基因结合的Desmin通过参与与nkx2.5基因相互作用的转录因子复合物进入心脏干细胞核并调节Nkx2.5表达

4. Ageing of the couplings between cardiac, respiratory and myogenic activity in humans [C] . Ticcinelli Valentina, Stankovski Tomislav, McClintock Peter V. E., Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：人的心脏，呼吸和肌源性活动之间的耦合老化

5. Estrogen and dehydroepiandrosterone protect cardiac myogenic (H9c2) cells against lethal heat shock-induced cell death. [D] . Al-khlaiwi, Thamir Mohammed N. 2002

机译：雌激素和脱氢表雄酮可保护心肌细胞（H9c2）免受致命的热激诱导的细胞死亡。

6. Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells. [O] . A Seiler-Tuyns, J D Eldridge, B M Paterson 1984

机译：鸡肌动蛋白基因的表达和调控引入小鼠肌原性和非肌原性细胞。

7. Subdivision of the Cardiac Nkx2.5 Expression Domain into Myogenic and Nonmyogenic Compartments [O] . Raffin Michael, Leong Li Ming, Rones Melissa S., 2000

机译：心脏Nkx2.5表达域细分为成肌和非成肌间隔

1. 肌肉特异性微小RNA和成肌调节因子在C2C12细胞成肌分化过程中的表达★ [J] . 宋佳 ,曾缨 ,郑民缨 . 中国组织工程研究 . 2012,第032期

2. 肌肉特异性微小RNA和成肌调节因子在C2C12细胞成肌分化过程中的表达 [J] . 宋佳 ,曾缨 ,郑民缨 . 中国组织工程研究 . 2012,第032期

3. 推拿手法对家兔骨骼肌失神经支配后成肌调节因子Myf-5、Myogenin表达的影响 [J] . 卢裕强 ,郭汝宝 . 浙江中西医结合杂志 . 2019,第012期

4. 成肌调节因子在共同性外斜视眼外肌中的表达及与临床病理学关系探讨 [J] . 马晓梅 ,李凌 ,杨进寿 . 临床眼科杂志 . 2019,第005期

5. 低频脉冲电磁场对肌卫星C2C12细胞增殖过程中成肌诱导因子5表达的影响 [J] . 杨兴辉 ,韩福军 ,毕佳琦 . 中华实验外科杂志 . 2016,第003期

6. 不同间隔时间下指压穴位刺激对脑卒中患者胫前肌和腓骨长、短肌的表面肌电影响 [C] . 葛瑞东 ,白硕 ,徐瑞泽 . 中国中医药研究促进会针灸康复分会第二届学术年会暨山东针灸学会第九届学术年会 . 2017

7. 成肌调节因子和肌抑制素在大鼠失神经骨骼肌的表达 [A] . 董进 . 2015

1. 骨骼肌周成血管细胞和心脏中成血管细胞、其分离方法和用途 [P] . 中国专利： CN101384706B . 2013.11.06

2. 骨骼肌周成血管细胞和心脏中成血管细胞、其分离方法和用途 [P] . 中国专利： CN101384706A . 2009-03-11

3. Domain refining treatment method and the magnetic domain subdivision processing unit [P] . 外国专利： JP5871128B2 . 2016-03-01

机译：畴细化处理方法和磁畴细分处理单元

4. adaptive subdivision of a chachespeicherraums in domains [P] . 外国专利： DE3390315T1 . 1985-02-21

机译：领域的chechpeicherraums的自适应细分

5. adaptive subdivision of a chachespeicherraums in domains [P] . 外国专利： DE000003390315T5 . 1985-02-21

机译：领域的chechpeicherraums的自适应细分

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Subdivision of the Cardiac Nkx2.5 Expression Domain into Myogenic and Nonmyogenic Compartments

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