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首页> 外文期刊>Developmental biology >The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system
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The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system

机译:Nkx5 / HMX同源域蛋白MLS-2是秀丽隐杆线虫排泄系统中正常管细胞形状所必需的

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Cellsperformwidevarietiesoffunctionsthatarefacilitated,inpart,byadoptinguniqueshapes.Manyofthegenesandpathwaysthatpromotecellfatespecificationhavebeenelucidated.However,relativelyfewtranscriptionfactorshavebeenidentifiedthatpromoteshapeacquisitionafterfatespecification.HereweshowthattheNkx5/HMXhomeodomainproteinMLS-2isrequiredforcellularelongationandshapemaintenanceoftwotubularepithelialcellsintheemC.elegans/emexcretorysystem,theductandporecells.TheNkx5/HMXfamilyishighlyconservedfromseaurchinstohumans,withknownrolesinneuronalandglialdevelopment.MLS-2isexpressedintheductandpore,anddefectsinemmls-2/emmutantsfirstarisewhentheductandporenormallyadoptuniqueshapes.MLS-2cooperateswiththeEGF-Ras-ERKpathwaytoturnontheLIN-48/Ovotranscriptionfactorintheductcellduringmorphogenesis.TheseresultsrevealanovelinteractionbetweentheNkx5/HMXfamilyandtheEGF-Raspathwayandimplicateatranscriptionfactor,MLS-2,asaregulatorofcellshape./p/div
机译:Cellsperformwidevarietiesoffunctionsthatarefacilitated,inpart,byadoptinguniqueshapes.Manyofthegenesandpathwaysthatpromotecellfatespecificationhavebeenelucidated.However,relativelyfewtranscriptionfactorshavebeenidentifiedthatpromoteshapeacquisitionafterfatespecification.HereweshowthattheNkx5 / HMXhomeodomainproteinMLS-2isrequiredforcellularelongationandshapemaintenanceoftwotubularepithelialcellsinthe 线虫 excretorysystem,theductandporecells.TheNkx5 / HMXfamilyishighlyconservedfromseaurchinstohumans,withknownrolesinneuronalandglialdevelopment.MLS-2isexpressedintheductandpore,anddefectsin MLS-2

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