Synthesis and Antitumor Activity of Some New Symmetrical Diselenide Derivatives.

摘要

ABSTRACT A convenient method for the synthesis of new organoselenium compounds was described from simple 2methoxy-4-selenocyanato-aniline (1) and its corresponding diselenide 2. The chemical reactivity of N,N'-(diselanediylbis(2methoxy-4,1-phenylene))bis-(2-chloro-acetamide) (3) was investigated towards several type of carbon and sulfur nucleophiles to furnish various heterocyclic diselenide derivatives. Moreover, the new synthesized compounds were evaluated for their antitumor activity and wer.