Synthesis, Molecular Docking and Cytotoxicity Evaluation of Novel 1,2-Disubstituted Benzimidazole Derivatives Against Liver and Breast Cancer Cell Lines.

摘要

ABSTRACT A series of novel 1, 2-disubstituted benzo[d]imidazole derivatives was synthesized, which bearing at position-1 different bioactive side chains or heterocyclic moieties. While, they are linked to 2,4,6-trisubstituted pyridine ring at position-2. In vitro Cytotoxic evaluation of all the new synthesized benzimidazole compounds (315a,b) against hepatocellular carcinoma (HepG-2) and breast carcinoma (MCF-7) cell lines showed that most of them gave significant cytotoxicity. Moreover, compou.