DESIGN,MOLECULAR DOCKING,SYNTHESIS AND ANTI-FUNGAL ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES

摘要

Benzimidazole is a heterocyclic compound with an extensive range of biological activities.Benzimidazole and its derivatives are the most resourceful classes of molecules against microorganisms.The increase in anti-microbial resistance to existing drugs necessitated the search for new molecules for the treatment of fungal infections1.Hence,aim of the present study is to design benzimidazole derivatives by molecular docking approach against selected fungal targets to understand binding conformation and interactions at the active pocket of respective targets and binding affinity of compounds was evaluated in terms of docking score.Selected benzimidazole derivatives were synthesized and screened for anti-fungal activity by Zone of inhibition method.