Genotoxicity and Ultrastructural Studies of the Effect of Cisplatin on the Cortex of Kidney of Albino Male Mice.

摘要

ABSTRACT Cisplatin is still a frequently used chemotherapeutic agent, despite of its frequent adverse effects, including nephrotoxicity. The present work was done to investigate its harmful effects on the tissue kidney of the male mice. Two groups of mice were injected intraperitoneally with 0.5 ml cisplatin at doses of 0.15 and 0.3 mg/kg BW, two times/weak, for four consecutive weeks. The third group animals was injected with 0.5 ml saline solution as a vehicle, and considered as a control. Ch.