Formulation of Immediate Release Tablets of Rabeprazole Sodium by Using Tablet in Tablet Technology.

摘要

ABSTRACT Rabeprazole provided effective control of gastric acid in patients with symptoms of gastroesophageal reflux. The present work was carried out to improve the therapeutic efficacy of Rabeprazole by expediting its onset of action. Rabeprazole is unstable in acidic environment which requires the drug in immediate release tablet to be delivered in an alkaline environment to enhance the in vivo stability of Rabeprazole. The tablets were prepared by using Tablet-in-Tablet technology, in which.