p38 MAPK pathway is involved in high glucose‐induced thioredoxin interacting protein induction in mouse mesangial cells

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p38 MAPK pathway is involved in high glucose‐induced thioredoxin interacting protein induction in mouse mesangial cells

机译：p38 MAPK通路参与小鼠系膜细胞中高糖诱导的硫氧还蛋白相互作用蛋白的诱导

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Excessivereactiveoxygenspecies(ROS)playakeyroleinthepathogenesisofdiabeticnephropathy.Thethioredoxin(TRX)system,amajorthiolantioxidantsystem,regulatesthereductionofintracellularROS.Hereweshowthathighglucose(HG)inhibitsTRXROS‐scavengingfunctionthroughp38mitogen‐activatedproteinkinase(MAPK)‐mediatedinductionofthioredoxininteractingprotein(TXNIP)inmousemesangialcells(MMCs).KnockdownofTXNIPinMMCsreversedHG‐inducedreductionofTRXactivityandinhibitedHG‐inducedactivationofp38MAPKandincreasedsynthesisofTGF‐β1andfibronectin.ThesedatasuggestthatHG‐inducedoverexpressionofTXNIPinMMCs,whichmaybeviathep38MAPKpathway...

机译：Excessivereactiveoxygenspecies（ROS）playakeyroleinthepathogenesisofdiabeticnephropathy.Thethioredoxin（TRX）系统，amajorthiolantioxidantsystem，regulatesthereductionofintracellularROS.Hereweshowthathighglucose（HG）inhibitsTRXROS-scavengingfunctionthroughp38mitogen-activatedproteinkinase（MAPK）-mediatedinductionofthioredoxininteractingprotein（TXNIP）inmousemesangialcells材料（MMC）.KnockdownofTXNIPinMMCsreversedHG-inducedreductionofTRXactivityandinhibitedHG-inducedactivationofp38MAPKandincreasedsynthesisofTGF-β1andfibronectin.ThesedatasuggestthatHG-inducedoverexpressionofTXNIPinMMCs，可能是通过p38MAPK途径...

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《FEBS Letters》 |2010年第15期|共6页
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1. p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells. [J] . Ren Y, Shi Y, Wang Y, FEBS letters. . 2010,第15期

机译：p38 MAPK通路参与小鼠肾小球系膜细胞中高葡萄糖诱导的硫氧还蛋白相互作用蛋白的诱导。
2. Knockdown of thioredoxin interacting protein attenuates high glucose‐induced apoptosis and activation of ASK1 in mouse mesangial cells [J] . FEBS Letters . 2011,第12期

机译：敲低硫氧还蛋白相互作用蛋白可减弱高糖诱导的小鼠系膜细胞凋亡和ASK1的活化
3. A G protein-associated ERK pathway is involved in LPS-induced proliferation and a PTK-associated p38 MAPK pathway is involved in LPS-induced differentiation in resting B cells. [J] . Kim J, Yang HY, Jang YS Molecular Immunology . 2006,第8期

机译：G蛋白相关的ERK途径参与LPS诱导的增殖，而PTK相关的p38 MAPK途径参与LPS诱导的静息B细胞分化。
4. Lipopolysaccharide (LPS)-induced signaling in human endothelial cells (EC). Roles of G proteins and the p38 MAP kinase pathway [C] . Aninda Das, Yiping Jio, Moshe Arditi NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：脂多糖（LPS）诱导人体内皮细胞（EC）中的信号传导。 G蛋白的作用和P38映射激酶途径
5. Cleavage of the pro-survival protein intersectin-1s by granzyme B induces endothelial cell proliferation via activation of p38 MAPK and Elk-1 transcription factor. [D] . Patel, Monal. 2010

机译：颗粒酶B切割促存活蛋白intersectin-1s通过激活p38 MAPK和Elk-1转录因子诱导内皮细胞增殖。
6. Up-regulation of Thioredoxin Interacting Protein (Txnip) by p38 MAPK and FOXO1 Contributes to the Impaired Thioredoxin Activity and Increased ROS in Glucose- treated Endothelial Cells [O] . Xiaonan Li, Yuanyuan Rong, Mei Zhang, -1

机译：p38 MAPK和FOXO1上调硫氧还蛋白相互作用蛋白（Txnip）有助于葡萄糖处理的内皮细胞中硫氧还蛋白活性受损和ROS升高
7. p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells [O] . Ren Yunzhuo, Shi Yonghong, Wang Yuehua, 2010

机译：p38 MAPK途径参与小鼠肾小球系膜细胞中高糖诱导的硫氧还蛋白相互作用蛋白的诱导

p38 MAPK pathway is involved in high glucose‐induced thioredoxin interacting protein induction in mouse mesangial cells

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