The Study of the Analgesic Activity of Fluoxetine and its Interactions with Morphine, Naltrexone and Ondansetron in Mice.

摘要

ABSTRACT Present study is conducted to evaluate analgesic activity of fluoxetine and to study its interactions with morphine, naltrexone and ondansetron in albino mice.The analgesic activity of fluoxetine (2, 5 & 10mg/kg) and its interactions with morphine (0.5mg/kg), naltrexone (5mg/kg) & ondansetron (1mg/kg) were studied by tail flick method. Fluoxetine at 2mg/kg did not produce significant analgesic effect but at doses 5 & 10 mg/kg produced significant dose dependent analgesia. Morphine in s.