Communication of Signals and Responses Leading To Cell Death Using Engineered Regulatory Networks

摘要

ABSTRACT This paper demonstrates the cell death/ apoptosis pathways considering three inputs Tumor Necrosis Factor (TNF), Epidermal Growth factor (EGF) and Insulin. Basically death pathway is a two process pathway: extrinsic pathway and intrinsic pathway. Later on pathways are converted into truth tables considering `1' as cell survival and `0' as cell death. The truth tables are implemented in VHDL using XILINX ISE, CMOS using SPICE and Fuzzy Logic using MATLAB. Out of three processes Fuzzy Lo.