Synthesis and Evaluation of Some Novel 5-[4-(substituted) benzylidene] 2.4 thiazolidinediones as Oral Antihyperglycemic Agents

摘要

ABSTRACT Thiazolidinediones(TZDs) are a new class of antidiabetic drugs, having an insulin sensitizing effect in patients with type 2 diabetes. A few 5-[4-(substituted) benzylidene]-2,4-thiazolidinediones have been designed, synthesized and evaluated as oral antihyperglycemic agents by fructose loaded model. 1,3-thiazolidine-2,4dione was prepared with the simple reaction of chloroacetic acid (mono) and thiourea. Knoevenagel condensation was also used for preparation of Thiazolidinediones. After.