Shellac Wax-Lutrol F127 as Matrix Base for Hot Melt Extrusion

摘要

ABSTRACT Minitablet prepared from hot melt extrusion (HME) has many benefits such as increasing of bioavailability and reducing of dose dumping. This study aimed to prepare the minitablet using 3:7, 4:6, 6:4 and 7:3 shellac wax (SW):Lutrol F127 (Lut) as the matrix base. The 10, 20, 30 and 40% ibuprofen were incorporated into 7:3 SW:Lut to prepare the minitablet by HME. Each of them was then characterized their morphology, physico-chemical properties, drug release and release kinetic. Morphologi.