The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

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The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

机译：CLIC蛋白的谜团：离子通道，氧化还原蛋白，酶，支架蛋白？

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Chlorideintracellularchannelproteins(CLICs)aredistinctfrommostionchannelsinthattheyhavebothsolubleandintegralmembraneforms.CLICsarehighlyconservedinchordates,withsixvertebrateparalogues.CLIC‐likeproteinsarefoundinothermetazoans.CLICsformchannelsinartificialbilayersinaprocessfavouredbyoxidisingconditionsandlowpH.Theyarestructurallyplastic,withCLIC1adoptingtwodistinctsolubleconformations.PhylogeneticandstructuraldataindicatethatCLICsarelikelytohaveenzymaticfunction.ThephysiologicalroleofCLICsappearstobemaintenanceofintracellularmembranes,whichisassociatedwithtubulogenesisbutmayinvolveothersubstructures...

机译：Chlorideintracellularchannelproteins（CLICS）aredistinctfrommostionchannelsinthattheyhavebothsolubleandintegralmembraneforms.CLICsarehighlyconservedinchordates，withsixvertebrateparalogues.CLIC-likeproteinsarefoundinothermetazoans.CLICsformchannelsinartificialbilayersinaprocessfavouredbyoxidisingconditionsandlowpH.Theyarestructurallyplastic，withCLIC1adoptingtwodistinctsolubleconformations.PhylogeneticandstructuraldataindicatethatCLICsarelikelytohaveenzymaticfunction.ThephysiologicalroleofCLICsappearstobemaintenanceofintracellularmembranes，whichisassociatedwithtubulogenesisbutmayinvolveothersubstructures ...

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《FEBS Letters》 |2010年第10期|共9页
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1. The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? [J] . Littler DR, Harrop SJ, Goodchild SC, FEBS letters. . 2010,第10期

机译：CLIC蛋白的谜团：离子通道，氧化还原蛋白，酶，支架蛋白？
2. Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets [J] . Peretti Marta, Angelini Marina, Savalli Nicoletta, Biochimica et biophysica acta. Biomembranes . 2015,第10aPta2期

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3. Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling [J] . Arteriosclerosis, thrombosis, and vascular biology . 2020,第7期

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4. Electron transfer between redox enzymes and electrodes through the artificial redox proteins and its applciatin for biosensors [C] . Hiroaki Shinohara, Taichi Kusaka, Eisaku Yokota, International meeting on chemical sensors . 1998

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5. Protein sorting and trafficking by neuronal adaptor proteins: Characterization of a conserved dendritic targeting motif on Kv4 channels and endocytic sorting of amyloid precursor protein by Mint2/X11L [D] . Chaufty, Jeremy Charles 2012

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6. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome [O] . Raquel Domingo-Fernández, Rebecca C. Coll, Jay Kearney, 2017

机译：细胞内氯通道蛋白CLIC1和CLIC4诱导IL-1β转录并激活NLRP3炎性体
7. The Enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? [O] . Littler, Dene R, Harrop, Stephen J, Curmi, Paul M.G, 2010

机译：CLIC蛋白的谜团：离子通道，氧化还原蛋白，酶，支架蛋白？

The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

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