S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection

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S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection

机译：Keap1的S-谷胱甘肽酰化：谷胱甘肽S-转移酶pi在神经元保护中的新作用

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OxidativestressisakeypathologicalfeatureofParkinson'sdisease(PD).GlutathioneS‐transferasepi(GSTP)isaneuroprotectiveantioxidantenzymeregulatedatthetranscriptionallevelbytheantioxidantmasterregulatornuclearfactor‐erythroid2‐relatedfactor2(Nrf2).Here,weshowforthefirsttimethatuponMPTP‐inducedoxidativestress,GSTPpotentiatesS‐glutathionylationofKelch‐likeECH‐associatedprotein1(Keap1),anendogenousrepressorofNrf2,invivo.S‐glutathionylationofKeap1leadstoNrf2activationandsubsequentlyincreasesexpressionofGSTP.ThispositivefeedbackregulatorylooprepresentsanovelmechanismbywhichGSTPelicitsantioxidantprotectioninthebrain...

机译：OxidativestressisakeypathologicalfeatureofParkinson'sdisease（PD）.GlutathioneS-transferasepi（GSTP）isaneuroprotectiveantioxidantenzymeregulatedatthetranscriptionallevelbytheantioxidantmasterregulatornuclearfactor-erythroid2-relatedfactor2（Nrf2的）。在这里，weshowforthefirsttimethatuponMPTP-inducedoxidativestress，GSTPpotentiatesS-glutathionylationofKelch-likeECH-associatedprotein1（Keap1的），anendogenousrepressorofNrf2，invivo.S-glutathionylationofKeap1leadstoNrf2activationandsubsequentlyincreasesexpressionofGSTP.ThispositivefeedbackregulatorylooprepresentsanovelmechanismbywhichGSTPelicitsantioxidantprotectioninthebrain .. 。

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《FEBS Letters 》 |2016年第10期| 共12页
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1. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection [J] . Carvalho Andreia Neves, Marques Carla, Guedes Rita C., FEBS letters. . 2016 ,第10期

机译：Keap1的S-谷胱甘肽酰化：谷胱甘肽S-转移酶pi在神经元保护中的新作用
2. Effect of glutathione, glutathione sulphonate and S‐hexylglutathione on the conformational stability of class pi glutathione S‐transferase [J] . Dirr Heini, Erhardt Julija FEBS Letters . 1996 ,第3期

机译：谷胱甘肽，谷胱甘肽和S-己基戊酰胺对PI谷胱甘肽S-转移酶构象稳定性的影响
3. A subgroup of class α glutathione S‐transferases Cloning of cDNA for mouse lung glutathione S‐transferase GST 5.7 [J] . Awasthi Yogesh C., Eckles Michael A., Saxena Manju, FEBS Letters . 1992 ,第2期

机译：小鼠肺谷胱甘肽S-转移酶GST 5.7的一个亚类谷胱甘肽S-转移酶的cDNA克隆
4. Glutathione S-Transferase pi Trapping Approach for the Characterization of Reactive Metabolites in Human Liver Microsomes [C] . Hideo Yukinaga, Haruo Iwabuchi, Osamu Okazaki, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：谷胱甘肽S-转移酶PI捕获方法，用于表征人肝微粒体的反应性代谢物
5. Role of the glutathione S-transferase P1 (GSTP1) electrophile binding site (H-site) in protection from doxorubicin-mediated cytotoxicity. [D] . Stephenson, Susan Toole. 2005

机译：谷胱甘肽S-转移酶P1（GSTP1）亲电结合位点（H-位点）在免受阿霉素介导的细胞毒性作用中的作用。
6. A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle [O] . Deepthi Menon, Philip G. Board 2013

机译：谷胱甘肽转移酶Omega 1（GSTO1-1）在谷胱甘肽化周期中的作用。
7. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer [O] . Kenneth D. Tew, Yefim Manevich, Christina Grek, 2011

机译：谷胱甘肽S-转移酶P在癌症中信号通路和S-谷胱甘肽中的作用

S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection

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