Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors

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Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors

机译：与人类DP前列腺素受体相比，人类EP2前列腺素受体对突变表现出更多的限制

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HumanD‐typeprostanoid(DP)andE‐typeprostanoid2(EP2)receptorsareregardedasthemostcloselyrelatedreceptorsamongprostanoidreceptors.Althoughthesereceptorsaregeneratedbytandemduplication,theirphysiologicaloutputsoftenopposeoneanother.Inthepresentstudy,weextractedmutationsoccurringinthecodingregionsofbothreceptorsusingthe1000genomeprojectdatabaseandfoundthatEP2receptorshave8‐foldfeweraminoacidmutations.WespeculatethatEP2receptorsexhibitmoreconstraintstomutationsthanDPreceptors...

机译：HumanD-typeprostanoid（DP）和E-typeprostanoid2（EP2）receptorsareregardedasthemostcloselyrelatedreceptorsamongprostanoidreceptors.Althoughthesereceptorsaregeneratedbytandemduplication，theirphysiologicaloutputsoftenopposeoneanother.Inthepresentstudy，weextractedmutationsoccurringinthecodingregionsofbothreceptorsusingthe1000genomeprojectdatabaseandfoundthatEP2receptorshave8-foldfeweraminoacidmutations.WespeculatethatEP2receptorsexhibitmoreconstraintstomutationsthanDPreceptors ...

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《FEBS Letters》 |2015年第6期|共7页
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1. Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors [J] . Tanimoto Jun, Fujino Hiromichi, Takahashi Hiroki, FEBS letters. . 2015,第6期

机译：与人类DP前列腺素受体相比，人类EP2前列腺素受体对突变表现出更多的限制
2. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands [J] . Suganami Akiko, Fujino Hiromichi, Okura Iori, The FEBS journal . 2016,第21期

机译：人类DP和EP2前列腺素受体根据不同配体的不同结合呈不同形式
3. Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved. [J] . Jozefowski S, Bobek M, Marcinkiewicz J International immunopharmacology . 2003,第6期

机译：外源而非内源性前列腺素调节鼠骨髓树突细胞的细胞因子分泌：涉及EP2，DP和IP，但不涉及EP1，EP3和FP前列腺素受体。
4. Aspirin-Sensitive Rhinosinusitis Is Associated with Reduced E-Prostanoid 2 (EP2) Receptor Expression on Nasal Mucosal Inflammatory Cells [C] . S. YingQ. Meng, G. Scadding, A. Parikh, Collegium Internationale Allergologicum . 2007

机译：阿司匹林敏感性鼻窦炎与鼻黏膜炎性细胞上的E-Frostanoid 2（EP2）受体表达有关
5. Activation of novel signal transduction pathways by human EP1 prostanoid receptors: The G-protein coupled receptors for prostaglandin E2. [D] . Ji, Ruyue. 2010

机译：人类EP1前列腺素受体激活新的信号转导途径：前列腺素E2的G蛋白偶联受体。
6. Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4 EP2 DP and IP receptor subtypes [O] . Richard J Wilson, Heather Giles 2005

机译：仔猪大隐静脉含有多种松弛类前列腺素受体：EP4EP2DP和IP受体亚型的证据
7. Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors [O] . Tanimoto Jun, Fujino Hiromichi, Takahashi Hiroki, 2015

机译：人类EP2前列腺素受体比人类DP前列腺素受体表现出更多的突变限制
8. Human Platelets Exhibit Chemotaxis using Functional N-Formyl Peptide Receptors [R] . Czapiga, M. , Gao, J. , Kirk, A. , 2005

机译：人血小板使用功能性N-甲酰肽受体展示趋化性

Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors

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