Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

Pinkas-Kramarski Ronit; Sokolovsky Mordechai; Stein Reuven; Zimmer Yitzhak

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Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

机译：克隆的大鼠M3毒蕈碱受体介导磷酸肌醇水解，但不抑制腺苷酸环化酶

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>Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.

机译：pRat M3 mAChR亚型在RAT 1细胞中稳定表达。克隆的M3受体的药理和生化特性研究表明，它们介导磷酸肌醇水解，但不介导腺苷酸环化酶抑制作用。讨论了克隆的大鼠M1和M3受体的特性之间的异同。

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《FEBS Letters》 |1988年第2期|共页
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Pinkas-Kramarski Ronit; Sokolovsky Mordechai; Stein Reuven; Zimmer Yitzhak;
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中图分类分子生物学;
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1. Pertussis toxin distinguishes between muscarinic receptor‐mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells [J] . Hughes John, Lo William W.Y. FEBS Letters . 1987,第1期

机译：百日咳毒素可区分毒蕈碱受体介导的腺苷酸环化酶抑制和Flow 9000细胞中磷酸肌醇水解的刺激
2. Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor [J] . Maria C.Olianas, Carlo Maullu, Pierluigi Onali British Journal of Pharmacology . 1997,第3期

机译：氯氮平对大鼠纹状毒蕈碱受体的抑制与腺苷酸环化酶活性的抑制以及对人类克隆的m4受体的影响
3. MUSCARINIC RECEPTOR - MEDIATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT BRAIN [J] . Hülya Cabadak, Beki Kan Marmara Medical Journal . 2016,第1期

机译：肌肉受体介导的大鼠脑中磷脂酰水解。
4. Cloning and Characterization of Rat Bile Salt Export Pump Promoter: Bile Acid Activation Is Mediated Via Farnesoid X Receptor/bile Acid Receptor [C] . N. Balasubramaniyan, F. J. Suchy, M. Ananthanarayanan Falk Symposium . 2003

机译：大鼠胆汁盐出口泵启动子的克隆与表征：胆汁酸活化是通过法呢X受体/胆汁酸受体介导的
5. ASSOCIATION OF SUBTYPES OF THE MUSCARINIC CHOLINERGIC RECEPTOR WITH DISTINCT BIOCHEMICAL RESPONSES (PHOSPHOINOSITIDE METABOLISM, ADENYLATE CYCLASE) [D] . GIL, DANIEL WALTER. 1985

机译：肌肉胆碱受体的亚型与不同的生物化学反应的关联（光化学代谢，腺苷酸环化）
6. Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover. [O] . R Stein, R Pinkas-Kramarski, M Sokolovsky 1988

机译：克隆的M1毒蕈碱受体介导腺苷酸环化酶抑制和磷酸肌醇转换。
7. Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition [O] . Pinkas-Kramarski Ronit, Stein Reuven, Zimmer Yitzhak, 1988

机译：克隆的大鼠M3毒蕈碱受体介导磷酸肌醇水解，但不抑制腺苷酸环化酶
8. Aluminum Decreases Muscarinic, Adrenergic and Metabotropic Receptor-Stimulated Phosphoinositide Hydrolysis in Hippocampal and Cortical Slices from Rat Brain [R] . Shafer, T. J., Mundy, W. R., Tilson, H. A. 1993

机译：铝减少大鼠脑海马和皮质切片中的毒蕈碱，肾上腺素能和代谢受体刺激的磷酸肌醇水解

Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

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