Ile‐Ser‐bradykinin (T‐kinin) and Met‐Ile‐Ser‐bradykinin (Met‐T‐kinin) are released from T‐kininogen by an acid proteinase of granulomatous tissues in rats

摘要

>An acid proteinase of granulomatous tissues in rats with carrageenin-induced inflammation released kinin from T-kininogen. The kinin isolated by n-butanol extraction was separated by reverse-phase high-performance liquid chromatography into T-kinin and a T-kinin derivative. From determination of its amino acid composition and its immunoreactivity toward anti-bradykinin antiserum, the T-kinin derivative was identified as Met-Ile-Ser-bradykinin (Met-T-kinin).