Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1

KAR NENG LAI; LORETTA Y Y CHAN; SYDNEY C W TANG; ANITA W L TSANG; FELIX F K LI; MAN FAI LAM; SING LEUNG LUI; JOSEPH C K LEUNG

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Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1

机译：血管紧张素Ⅱ受体的肾小球系膜在IgA肾病中的表达及其对聚合物IgA1的调控

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Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1.BackgroundEnhanced gene expression for the renin-angiotensin system (RAS) is detected in glomerular mesangial cells in IgA nephropathy (IgAN). Preliminary studies showed a reduced glomerular gene expression of angiotensin II subtype 1 receptor (AT1R), suggesting a regulatory response to high intrarenal angiotensin II (Ang II) concentration in IgAN.

机译：IgA肾病中血管紧张素II受体的肾小球系膜表达及其受聚合IgA1的调节背景在IgA肾病（IgAN）的肾小球系膜细胞中检测到肾素-血管紧张素系统（RAS）的基因表达增强。初步研究表明，血管紧张素II亚型1受体（AT1R）的肾小球基因表达降低，表明对IgAN中高肾内血管紧张素II（Ang II）浓度的调节反应。

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《Kidney international.》 |2004年第4期|共14页
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KAR NENG LAI; LORETTA Y Y CHAN; SYDNEY C W TANG; ANITA W L TSANG; FELIX F K LI; MAN FAI LAM; SING LEUNG LUI; JOSEPH C K LEUNG;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 [J] . KAR NENG LAI, LORETTA Y Y CHAN, SYDNEY C W TANG, Kidney international. . 2004,第4期

机译：血管紧张素Ⅱ受体的肾小球系膜在IgA肾病中的表达及其对聚合物IgA1的调控
2. Engagement of Transferrin Receptor by Polymeric IgA1: Evidence for a Positive Feedback Loop Involving Increased Receptor Expression and Mesangial Cell Proliferation in IgA Nephropathy [J] . Abdelaziz Gdoura, Charlotte Sadaka, Elie Haddad, Journal of the American Society of Nephrology: JASN . 2005,第9期

机译：聚合的IgA1的转铁蛋白受体的参与：涉及增加的IgA肾病受体表达和肾小球膜细胞增殖的正反馈环的证据。
3. Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. [J] . Moura IC, Arcos Fajardo M, Gdoura A, Journal of the American Society of Nephrology: JASN . 2005,第9期

机译：聚合IgA1与转铁蛋白受体的结合：证据表明阳性反馈环涉及IgA肾病中受体表达增加和系膜细胞增殖。
4. Transferrin Receptor Engagement by Polymeric IgAI Induces Receptor Expression and Mesangial Cell Proliferation: Role in IgA Nephropathy [C] . Houda Tamouza, Florence Vende, Meetu Tiwari, International Symposium on IgA Nephropathy . 2007

机译：通过聚合物Igai诱导受体表达和Mesangial细胞增殖的转铁蛋白受体接合：在IgA肾病中的作用
5. Novel mechanisms of cardioprotection: Catecholamine release by natriuretic peptides: Characterization and prevention; activation of ALDH2 in mast cell mitochondria: Prevention of local angiotensin II formation; activation of histamine H3-receptors: Reduction of angiotensin AT1-receptor neuronal expression [D] . Chan, Noel Yan-ki 2012

机译：心脏保护的新机制：利钠肽释放儿茶酚胺：表征和预防；肥大细胞线粒体中ALDH2的激活：预防局部血管紧张素II的形成； H3受体的活化：降低血管紧张素AT1受体神经元表达
6. Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy [O] . Ye-Ping Ma, Yue Yang, Shi-Min Jiang, 2020

机译：血管紧张素II 1型受体阻滞剂对糖尿病性肾病患者的肾脏血管紧张素II和MAS受体表达有积极影响
7. Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 [O] . Lai, KN, Chan, LYY, Tang, SCW, 2004

机译：血管紧张素Ⅱ受体在Iga肾病中的系膜表达及其对聚合Iga1的调节作用

Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1

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