Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats

AKIRA NISHIYAMA; MASANORI YOSHIZUMI; MATLUBUR RAHMAN; HIROYUKI KOBORI; DALE M SETH; AKIRA MIYATAKE; GUO-XING ZHANG; LI YAO; HIROFUMI HITOMI; TAKATOMI SHOKOJI; HIDEYASU KIYOMOTO; SHOJI KIMURA; TOSHIAKI TAMAKI; MASAKAZU KOHNO; YOUICHI ABE

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Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats

机译：AT1受体阻滞剂对Dahl盐敏感性大鼠肾脏损伤和丝裂原激活蛋白活性的影响

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Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.BackgroundThe mitogen-activated protein kinase (MAPK) cascade is an important intracellular mediator of angiotensin II (Ang II)-induced cell growth and differentiation. Here, we examined the effect of angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and MAPK activity in Dahl salt-sensitive (DS) rats.

机译：AT1受体阻滞剂对Dahl盐敏感性大鼠肾脏损伤和丝裂原激活蛋白活性的影响。背景丝裂原激活蛋白激酶（MAPK）级联是血管紧张素II（Ang II）诱导的细胞生长和分化的重要细胞内介质。在这里，我们检查了血管紧张素II 1型受体（AT1）受体阻滞对Dahl盐敏感（DS）大鼠肾损伤和MAPK活性的影响。

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《Kidney international.》 |2004年第3期|共10页
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AKIRA NISHIYAMA; MASANORI YOSHIZUMI; MATLUBUR RAHMAN; HIROYUKI KOBORI; DALE M SETH; AKIRA MIYATAKE; GUO-XING ZHANG; LI YAO; HIROFUMI HITOMI; TAKATOMI SHOKOJI; HIDEYASU KIYOMOTO; SHOJI KIMURA; TOSHIAKI TAMAKI; MASAKAZU KOHNO; YOUICHI ABE;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats [J] . AKIRA NISHIYAMA, MASANORI YOSHIZUMI, MATLUBUR RAHMAN, Kidney international. . 2004,第3期

机译：AT1受体阻滞剂对Dahl盐敏感性大鼠肾脏损伤和丝裂原激活蛋白活性的影响
2. Effects of chronic inhibition of ACE and AT1 receptors on glomerular injury in dahl salt-sensitive rats. [J] . Otsuka F, Yamauchi T, Kataoka H, American Journal of Physiology . 1998,第6aPta2期

机译：慢性抑制ACE和AT1受体对dahl盐敏感性大鼠肾小球损伤的影响。
3. Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats. [J] . Pelisch N, Hosomi N, Ueno M, American Journal of Hypertension . 2011,第3期

机译：AT1受体的阻断可保护Dahl盐敏感性高血压大鼠的血脑屏障并改善其认知。
4. Angiotensin II Augments Renal Vasoconstriction via AT1 Receptors in L-NAME-induced Hypertensive Rats [C] . Felipe Francisco Rivera-Jardon, Patricia Castro-Moreno, Edgar Saul Figueroa-Guillen, Western Pharmacology Society . 2009

机译：血管紧张素II通过L-Name诱导的高血压大鼠AT1受体增强肾血管收缩
5. Mitogen-activated protein kinases mediate angiotensin II-induced upregulation of AT1 receptors in the brain of heart failure rats . [D] . Wei, Shunguang. 2007

机译：丝裂原激活的蛋白激酶介导血管紧张素II诱导的心力衰竭大鼠脑中AT1受体的上调。
6. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats [O] . Akira Nishiyama, Masanori Yoshizumi, Matlubur Rahman, -1

机译：AT1受体阻滞剂对Dahl盐敏感性大鼠肾脏损伤和丝裂原激活蛋白活性的影响
7. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats [O] . Nishiyama Akira, Yoshizumi Masanori, Rahman Matlubur, 2004

机译：AT1受体阻滞对Dahl盐敏感大鼠肾脏损伤和丝裂原激活蛋白活性的影响

Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats

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