Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-|[beta]| signaling in mesangial cells

摘要

Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF- signaling in mesangial cells.BackgroundLipid abnormalities and oxidative stress may be involved in the development of glomerulosclerosis. Plasminogen activator inhibitor-1 (PAI-1) is a component of extracellular matrix (ECM) and target gene of transforming growth factor- (TGF-). Smad proteins play a key role in TGF- signaling, and Smad binding CAGA boxes are present in the PAI-1 promoter. This study examined whether oxidized low-density lipoprotein (Ox-LDL) activates PAI-1 transcription in human mesangial cells, mediated by increased Smad/DNA interactions.