Effect of acidosis on urine supersaturation and stone formation in genetic hypercalciuric stone-forming rats

摘要

Effect of acidosis on urine supersaturation and stone formation in genetic hypercalciuric stone-forming rats.BackgroundWe have successively inbred over 45 generations a strain of rats to maximize urine calcium excretion. The rats now consistently excrete 8 to 10 times as much calcium as controls and uniformly form poorly crystalline calcium phosphate kidney stones. In humans with calcium nephrolithiasis, consumption of a diet high in acid precursors is often cited as a risk factor for the development of calcium-based kidney stones; however, the effect of this diet on urinary supersaturation with respect to the common solid phases found in kidney stones has not been determined.