Regulation of renal proximal tubular epithelial cell hyaluronan generation: Implications for diabetic nephropathy

摘要

Regulation of renal proximal tubular epithelial cell hyaluronan generation: Implications for diabetic nephropathy.BackgroundProximal tubular cells (PTCs) contribute to pathological changes in the renal interstitium by the generation of cytokines and alterations in the composition of the extracellular matrix. Hyaluronan (HA) is a ubiquitous connective tissue polysaccharide that regulates cell function and tissue remodeling. In the current study, we investigated the regulation of HA generation by PTCs.