Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB

摘要

Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB.BackgroundAngiotensin II (Ang II) can up-regulate nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-). We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM).