The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2.

A Eisen; W E Taylor; H Blumberg; E T Young

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The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2.

机译：酵母调节蛋白ADR1以锌依赖性方式与ADH2的上游激活序列结合。

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The yeast ADR1 protein contains two zinc finger domains that are essential for its role in transcriptional activation of alcohol dehydrogenase (ADH2). These domains are thought to function as DNA-binding structures. An ADR1-beta-galactosidase fusion protein made in Escherichia coli and containing the finger domains of ADR1 binds in vitro in a zinc-dependent manner to DNA fragments containing the two ADH2 upstream activation sequences. The strongest binding is to upstream activation sequence 1, a 22-base-pair palindrome.

机译：酵母ADR1蛋白包含两个锌指结构域，这对于其在酒精脱氢酶（ADH2）转录激活中的作用至关重要。这些结构域被认为起着DNA结合结构的作用。在大肠杆菌中生产并含有ADR1指状结构域的ADR1-β-半乳糖苷酶融合蛋白在体外以锌依赖性方式与含有两个ADH2上游激活序列的DNA片段结合。最强的结合是上游激活序列1，一个22个碱基对的回文。

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《Molecular and Cellular Biology》 |1988年第10期|共5页
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A Eisen; W E Taylor; H Blumberg; E T Young;
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中图分类细胞生物学;
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1. Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABFI protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. [J] . P K Brindle, J P Holland, C E Willett, Molecular and Cellular Biology . 1990,第9期

机译：多种因素结合酵母烯醇化酶基因ENO1和ENO2的上游激活位点：ABFI蛋白像阻遏物激活蛋白RAP1一样，结合可调节转录抑制或激活的顺式作用序列。
2. Functional homology between the yeast regulatory proteins GAL4 and LAC9: LAC9-mediated transcriptional activation in Kluyveromyces lactis involves protein binding to a regulatory sequence homologous to the GAL4 protein-binding site. [J] . K D Breunig, P Kuger Molecular and Cellular Biology . 1987,第12期

机译：酵母调节蛋白GAL4和LAC9之间的功能同源性：乳酸克鲁维酵母中LAC9介导的转录激活涉及蛋白与与GAL4蛋白结合位点同源的调节序列的结合。
3. Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus. [J] . D Vujaklija, S Horinouchi, T Beppu Journal of bacteriology . 1993,第9期

机译：检测与strR上游激活序列结合的A因子响应蛋白，strR是灰链霉菌中链霉素生物合成的调控基因。
4. Properties of Sequence Conservation in Upstream Regulatory and Protein Coding Sequences among Paralogs in Arabidopsis thaliana [C] . Dale N. Richardson, Thomas Wiehe Comparative genomics . 2009

机译：拟南芥旁系同源物上游调控序列和蛋白质编码序列的序列保守性
5. Identification of regulatory elements in a conserved upstream region of the gene encoding interphotoreceptor retinoid-binding protein (IRBP). [D] . Lu, Haiyan. 1998

机译：鉴定编码光受体间类视黄醇结合蛋白（IRBP）的基因的保守上游区域中的调节元件。
6. The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2. [O] . A Eisen, W E Taylor, H Blumberg, 1988

机译：酵母调节蛋白ADR1以锌依赖性方式与ADH2的上游激活序列结合。
7. The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2. [O] . Eisen, A, Taylor, W E, Blumberg, H, 1988

机译：酵母调节蛋白ADR1以锌依赖性方式与ADH2的上游激活序列结合。

The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2.

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