402 JX-594, a targeted multi-mechanistic oncolytic poxvirus, infects tumor vasculature and causes acute tumor vascular disruption and necrosis in advanced cancer patients

C. Breitbach; R. Patt; N. De Silva; K. Parato; M. Daneshmand; T. Hickman; J.C. Bell; D.H. Kirn

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402 JX-594, a targeted multi-mechanistic oncolytic poxvirus, infects tumor vasculature and causes acute tumor vascular disruption and necrosis in advanced cancer patients

机译：402 JX-594是一种靶向多机制溶瘤性痘病毒，可感染肿瘤血管，并引起晚期癌症患者的急性肿瘤血管破裂和坏死

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来源
《European Journal of Cancer Supplements》 |2010年第7期|共页
作者
C. Breitbach; R. Patt; N. De Silva; K. Parato; M. Daneshmand; T. Hickman; J.C. Bell; D.H. Kirn;
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中图分类肿瘤学;
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1. A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma. [J] . Hwang TH, Moon A, Burke J, Molecular therapy: the journal of the American Society of Gene Therapy . 2011,第10期

机译：针对转移性黑素瘤患者的靶向多机制溶瘤性痘病毒JX-594的机制概念性临床试验。
2. The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma. [J] . Liu TC, Hwang T, Park BH, Molecular therapy: the journal of the American Society of Gene Therapy . 2008,第9期

机译：靶向溶瘤性痘病毒JX-594在肝细胞癌患者中表现出抗肿瘤，抗血管和抗HBV活性。
3. Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial. [J] . Park BH, Hwang T, Liu TC, The lancet oncology . 2008,第6期

机译：靶向溶瘤性痘病毒JX-594在难治性原发性或转移性肝癌患者中的应用：I期试验。
4. Enhanced Vascular Permeability in Solid Tumors and Tumor Targeted Delivery of Macromolecular Anticancer Drugs Based on EPR effect [C] . Hiroshi Maeda Proceedings of international symposium on crystal engineering and drug delivery system 2009 . 2009

机译：基于EPR效应的实体瘤血管通透性增强和大分子靶向抗肿瘤药物的肿瘤靶向递送
5. Development and evaluation of a tumor vasculature targeted liposome delivery system for a novel anti-vascular agent, combretastatin A4. [D] . Nallamothu, Ramakrishna. 2006

机译：肿瘤血管系统靶向脂质体递送系统的开发和评估，该系统用于新型抗血管药物康维他汀A4。
6. A Mechanistic Proof-of-concept Clinical Trial With JX-594 a Targeted Multi-mechanistic Oncolytic Poxvirus in Patients With Metastatic Melanoma [O] . Tae-Ho Hwang, Anne Moon, James Burke, 2011

机译：针对转移性黑素瘤患者的靶向多机制溶瘤性痘病毒JX-594的机制概念验证临床试验。
7. 50. Demonstration of Safety and Antitumoral Activity of JX-594, a Targeted Multi-Mechanistic Oncolytic Poxvirus, Following Intravenous Infusion and/or Intratumoral Injections in Patients with Refractory Metastatic Cancers [O] . 2011

机译：50. JX-594的安全性和抗肿瘤活性，A针对性多机械溶血性痘病毒，在难治性转移性癌症患者静脉内输注和/或妥善注射液之后
8. Prostate-Specific and Tumor-Specific Targeting of an Oncolytic HSV-1 Amplicon/Helper Virus for Prostate Cancer Treatment [R] . Lee, C. 2009

机译：针对前列腺癌治疗的溶瘤性HsV-1扩增子/辅助病毒的前列腺特异性和肿瘤特异性靶向

402 JX-594, a targeted multi-mechanistic oncolytic poxvirus, infects tumor vasculature and causes acute tumor vascular disruption and necrosis in advanced cancer patients

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