Purpose.: To evaluate the acceleration of pupil constriction (APC) in response to illumination using video anterior segment optical coherence tomography (AS-OCT) in angle closure and normal eyes. Methods.: This was an observational study of 342 Chinese subjects. Iris and angle changes in response to illumination were captured with real-time video recordings of AS-OCT and analyzed frame by frame. APC was calculated using a quadratic function, fitting pupil diameter to a time series. APC was divided into two vector components: acceleration of pupil block (APB) acting perpendicular to the lens surface and acceleration of iris stretch (AIS) acting toward the iris root. Results.: Of 342 eligible patients, 306 (89.5%) were available for analysis; of whom 136 (41.7%) had angle closure. After adjusting for age, sex, baseline pupil diameter, and iris thickness, APC was significantly lower in angle closure eyes (0.61 mm/s2) than in open-angle eyes (0.90 mm/s2) (P 0.0001) as was AIS (0.58 mm/s2 vs. 0.89 mm/s2) (P 0.001). APB was significantly higher in angle closure eyes compared to open-angle eyes (0.14 mm/s2 vs. 0.09 mm/s2) (P 0.001). After adjusting for age and sex in logistic regression, the magnitude and direction of all vector parameters were significantly associated with presence of angle closure. Conclusions.: Angle closure eyes have smaller AIS and larger APB in response to illumination as measured using AS-OCT videography. This shows that, comparatively, the iris of angle closure eyes stretches less and develops a more convex configuration in response to illumination.
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机译:目的:通过闭角和正常眼中的视频前段光学相干断层扫描(AS-OCT)评估瞳孔收缩(APC)对照明的响应速度。方法:这是一项对342名中国受试者的观察性研究。通过AS-OCT的实时视频记录来捕获响应于照明的虹膜和角度变化,并逐帧进行分析。使用二次函数计算APC,将瞳孔直径拟合到时间序列。 APC分为两个向量分量:垂直于晶状体表面起作用的瞳孔块(APB)的加速度和向虹膜根部起作用的虹膜拉伸的加速度(AIS)。结果:在342名合格患者中,有306名(89.5%)可供分析。其中136名(41.7%)患有闭角。在调整了年龄,性别,基线瞳孔直径和虹膜厚度后,闭角型眼(0.61 mm / s2)的APC显着低于开角型眼(0.90 mm / s2)(P <0.0001),而AIS( 0.58 mm / s2与0.89 mm / s2)(P <0.001)。与开角眼相比,闭角眼中的APB明显更高(0.14 mm / s2对0.09 mm / s2)(P <0.001)。在逻辑回归中调整了年龄和性别之后,所有矢量参数的大小和方向都与角度闭合的存在显着相关。结论:使用AS-OCT摄影技术测得,闭角眼对照明的响应具有较小的AIS和较大的APB。相对于此,这表明,闭角眼的虹膜伸展较少,并且响应于照明而形成更凸的构造。
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