The global population genetics of Dengue viruses revealed through temporal and spatial mapping of viral genetic variation

摘要

Purpose: Dengue viruses are a genetically diverse group of mosquito-borne RNA viruses that cause more than 300 million infections yearly worldwide. Numerous phylogenetic studies have shown that within each Dengue virus serotype, viruses can be clustered into Asian and American lineages based on their sequence similarity. However, the precise genetic variation that determine these groups, the frequencies and distributions of variants and the reasons behind these observed polymorphisms remain poorly understood and complicated by rapid molecular evolution of the viral genome.