METHOD FOR DIAGNOSING OR MONITORING CONDITIONS CHARACTERIZED BY ABNORMAL TEMPORAL VARIATIONS AND METHOD OF NORMALIZING EPIGENETIC DATA TO COMPENSATE FOR TEMPORAL VARIATIONS

摘要

Methods for diagnosing or monitoring a condition, disorder or disease associated with circadian, diurnal or other temporal rhythms by detecting circa-miRNAs and circa-microbiomes associated with said condition, disorder or disease. Methods for correcting or normalizing sequence data to correct for diurnal or circadian fluctuations in quantities of circa-miRNAs and/or circa-microbiomes by adjusting or normalizing values based on the time of day when a saliva sample containing these RNAs was collected.