Background: Accumulating evidences indicate that hepatitis E is a zoonosis. Pigs, rabbits and some other animal species are reservoirs for hepatitis E virus (HEV). This ubiquitous nature of HEV raises public health concern for zoonotic transmission and food safety in human population. The aim of this study was to investigate the prevalence of HEV infection in patients with hepatitis E and to analyze the molecular epidemiological characteristics of HEV strains prevalent in Shandong phylogenetically.
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