In vitro antimicrobial susceptibility of ceftriaxone/sulbactam/ethylenediaminetetraacetic acid and comparison to other beta-lactam/beta-lactamase inhibitors, carbapenems and colistin against gram negative bacteria

摘要

Background: Drug resistance against Gram Negative Bacteria (GNB) is increasing. Incidence of ESBL producing bacteria is around 70-80%. Carbapenem resistance has also been reached 40-90% for the GNB. We are also obtaining Colistin resistant isolates. Resistance against Beta-lactam (BL)/beta-lactamase inhibitor (BLI) combinations is already very high. No new antibiotic or antibiotic group is in pipeline at least for the next 5-10 years. With this background the objective of this study is to compare in vitro susceptibility of new BL/BLI combination Ceftriaxone/Sulbactam/Ethylenediaminetetraacetic Acid (CSE) to Piperacillin/Tazobactam, Cefoperazone/Sulbactam, Cefepime/Tazobactam, Meropenem, Imipenem and Colistin.