Mitochondrial dysfunction among HIV-1 infected patients of South India and evaluation of mitochondrial DNA as a biomarker of mitochondrial toxicity

摘要

Background: NRTI class of drugs though they cause mitochondrial toxicity, owing to their cost is the preferred class of drugs in resource-limited settings like India, hence there is a greater need to identify a novel biomarker of mitochondrial toxicity. In this study mitochondrial dysfunction was estimated from peripheral blood mononuclear cells (PBMCs) and the utility of mitochondrial DNA (mtDNA) as a marker of mitochondrial toxicity was evaluated.