Transcriptional response of AcrAB-TolC conferring carbapenems resistance within escherichia coli associated with community acquired infection

摘要

Background: Escherichia coli, an important member of Enterobacteriaceae is responsible for both hospital and community acquired infections. They have developed different mechanisms for survival in antibiotic stress. One of the well known mechanisms of resistance is the Efflux pump activity. These efflux pumps have the ability to export a wide range of compounds like antibiotics, detergents, organic solvents etc. A major tripartite multidrug efflux pump of Escherichia coli, AcrAB–TolC, confers resistance to a wide variety of compounds.