Characterization of Diversity in wbeT Region of the O-Antigen Biosynthesis Gene Cluster in Ogawa and Inaba Serotypes of Vibrio cholerae

摘要

Background: Vibrio cholerae serotypes O1 Inaba, O1 Ogawa serogroups have been associated with widespread cholera outbreaks which occur annually in Iran. An approximately 22?kb gene cluster is responsible for O1 antigen biosynthesis while serotype switching also occurs within this cluster in the genome of V. cholerae O1 strains. It has been identified that product of the wbeT region in the cluster is a transferase and is responsible for the expression of the B determinant, which is Ogawa-specific.