Canine furious and paralytic rabies: studies of neural tract integrity, blood brain barrier, virus and inflammatory distribution patterns

摘要

Background: Rabies fatality requires an impenetrable blood brain barrier (BBB) as one immune-evasive mechanism. Survival periods are longer in paralytic rabies with lower virus load in the brain than in furious rabies. Whether this phenomenon is associated with leak from BBB and more pronounced inflammation in the case of paralytic rabies is intriguing.