Photoacoustic assessment of nanoparticles distribution pattern in the mouse brain following blood-brain barrier (BBB) disruption

摘要

Focused ultrasound (FUS) with circulating microbubbles creates transient and reversible permeabilization of vasculatures which provides an essential means to deliver therapeutics and imaging agents, for instance across the BBB. We have previously shown that 3D color Doppler and photoacoustic imaging can monitor BBB disruption (BBBD) in mice. Here we study how changes in NPs size, concentration and dye properties play an important role in their spatial deposition.