Human beta-defensin 1 (hBD-1) is a 36-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. The objective of the study was to determine the antimicrobial properties and the bactericidal activity of synthetic hBD-1 against nosocomial pathogens belonging to 10 different bacterial species and exhibiting various antimicrobial resistance phenotypes. The native disulfide connectivity was found essential for the bactericidal activity of hBD-1, while sodium chloride concentration was reversely associated with its potency.
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