Monoclonal Paraprotein May Interfere with the Roche Direct HDL-C Plus Assay

摘要

We report here the observation of a falsely decreased HDL-cholesterol (HDL-C) result obtained with the Roche HDL-C Plus assay (polyethylene glycol-modified enzymes, sulfated α-cyclodextrin, and dextran sulfate; cat no. 1930648) in an asymptomatic 78-year-old woman (1). The total cholesterol of the patient was 3.2 mmol/L, the triglycerides were 1.3 mmol/L, and the HDL-C was suppressed (0) on a Roche Modular analyzer. The same analysis was repeated on the Johnson & Johnson Vitros (with magnetic separation of particles; cat. no. 1042523) and the Beckman LX-20 (with a polyanion-polymer/detergent reagent; cat. no. 650207) …