Apolipoprotein A-II Is a Negative Risk Indicator for Cardiovascular and Total Mortality: Findings from the Ludwigshafen Risk and Cardiovascular Health Study

摘要

Apolipoprotein A-II (apoA-II)1 was recently shown by Birjmohun and coworkers to be inversely associated with future risk for coronary artery disease in 912 cases and 1635 controls (1). This finding is important, because prior data have suggested that apoA-II has poor antiatherogenic properties and may even be proatherogenic. We now confirm and extend the antiatherogenic association of apoA-II to cardiac and total mortality on the basis of data collectd after 8 years of follow-up in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, which is investigating patients who underwent elective coronary angiography (2).Complete clinical and biochemical data from 3261 participants in the LURIC study are available. For these study participants, 752 deaths were recorded, and causes of death were obtained from official death certificates. Death from cardiac causes was recorded in 431 cases. Patients with …