Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

B Zhang; X Chen; S Bae; K Singh; M K Washington; P K Datta

首页> 外文期刊>British Journal of Cancer >Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

【24h】

Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

机译：大肠癌中Smad4的缺失通过激活Akt途径诱导对5-氟尿嘧啶的耐药性

获取原文

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background:Higher frequency of Smad4 inactivation or loss of expression is observed in metastasis of colorectal cancer (CRC) leading to unfavourable survival and contributes to chemoresistance. However, the molecular mechanism of how Smad4 regulates chemosensitivity of CRC is unknown.

机译：背景：在结直肠癌（CRC）的转移中观察到Smad4失活或表达缺失的频率更高，导致不良的生存率并导致化学耐药性。但是，尚不清楚Smad4如何调节CRC化学敏感性的分子机制。

著录项

来源
《British Journal of Cancer》 |2014年第4期|共12页
作者
B Zhang; X Chen; S Bae; K Singh; M K Washington; P K Datta;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer [J] . Yang Chao, Cui Xiaoxian, Dai Xiaoqin, Oncology letters . 2016,第2aPta2期

机译：Foxc2的下调通过激活MAPK和AKT途径在大肠癌中增强5-氟尿嘧啶诱导的凋亡
2. Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE(2) Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells [J] . Semaan Josiane, Pinon Aline, Rioux Benjamin, Journal of cellular biochemistry. . 2016,第12期

机译：通过激活人类HT-29和HCT116大肠癌细胞中的PI3K / Akt，MEK / ERK和p38 / COX-2 / PGE（2）途径对3-HTMC诱导的细胞凋亡的抗性。
3. Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE(2) Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells [J] . Semaan Josiane, Pinon Aline, Rioux Benjamin, Journal of cellular biochemistry. . 2016,第12期

机译：通过PI3K / AKT，MEK / ERK和P38 / COX-2 / PGE（2）途径在人HT-29和HCT116结直肠癌细胞中激活抗3-HTMC诱导的细胞凋亡
4. Sensitization of human colorectal cancer cells to paclitaxel- induced apoptosis by inhibition of MEK/ERK pathway is caspase-4 dependent [C] . NIZAR M. MHAIDAT, SAIED A. JARADAT, ABDULHAMEED GHABKARI Recent researches in modern medicine . 2011

机译：通过抑制MEK / ERK途径使大肠癌细胞对紫杉醇诱导的细胞凋亡的敏感性取决于caspase-4
5. Sensitivity of MCF-7 breast cancer cells to anticancer drugs is decreased by activation of the PI3K/PDK/Akt signal transduction pathway. [D] . Navolanic, Patrick M. 2004

机译：通过激活PI3K / PDK / Akt信号转导途径，MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
6. Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway [O] . B Zhang, B Zhang, X Chen, 2014

机译：大肠癌中Smad4的缺失通过激活Akt途径诱导对5-氟尿嘧啶的耐药性
7. Loss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway [O] . Ziyun Shao, Yanjun Cai, Lijun Xu, 2016

机译：14-3-3σ的损失对于通过激活PI3K / AKT信号通路的Lasp1介导的结肠直肠癌进展至关重要

Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

摘要

著录项

相似文献

相关主题

期刊订阅