In situ quantification of HER2|[ndash]|protein tyrosine kinase 6 (PTK6) protein|[ndash]|protein complexes in paraffin sections from breast cancer tissues

摘要

Background:Protein tyrosine kinase 6 (PTK6; breast tumour kinase) is overexpressed in up to 86% of the invasive breast cancers, and its association with the oncoprotein human epidermal growth factor receptor 2 (HER2) was shown in vitro by co-precipitation. Furthermore, expression of PTK6 in tumours is linked with the expression of HER2.