A novel fragment derived from the |[beta]| chain of human fibrinogen, |[beta]|43|[ndash]|63, is a potent inhibitor of activated endothelial cells in vitro and in vivo

摘要

Background:Angiogenesis and haemostasis are closely linked within tumours with many haemostatic proteins regulating tumour angiogenesis. Indeed we previously identified a fragment of human fibrinogen, fibrinogen E-fragment (FgnE) with potent anti-angiogenic properties in vitro and cytotoxic effects on tumour vessels in vivo. We therefore investigated which region of FgnE was mediating vessel cytotoxicity.