Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer

B Royer; W Yin; M Pegram; N Ibrahim; C Villanueva; D Mir; F Erlandsson; X Pivot

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Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer

机译：人源化单克隆抗体HuHMFG1（AS1402）的群体药代动力学，来自于乳腺癌的I期研究

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Background:HuHMFG1 (AS1402) is a humanised monoclonal antibody that has undergone a phase I trial in metastatic breast cancer. The aim of this study was to characterise the pharmacokinetics (PKs) of HuHMFG1 using a population PK model.

机译：背景：HuHMFG1（AS1402）是一种人源化单克隆抗体，已经在转移性乳腺癌中进行了I期试验。这项研究的目的是使用人口PK模型表征HuHMFG1的药代动力学（PKs）。

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《British Journal of Cancer》 |2010年第5期|共6页
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B Royer; W Yin; M Pegram; N Ibrahim; C Villanueva; D Mir; F Erlandsson; X Pivot;
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2. Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer [J] . Mark D Pegram, Virginia F Borges, Nuhad Ibrahim, Breast Cancer Research . 2009,第5期

机译：晚期乳腺癌患者静脉内人源化抗MUC1抗体AS1402的I期剂量递增药代动力学评估
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4. A Humanised Anti-IL-17BR Monoclonal Antibody with Wide Therapeutic Potential in Allergic Asthma, Ulcerative Colitis, Pulmonary Fibrosis and Pancreatic Cancer [C] . Seema Patel, Carolina Fernes, Richard Brown, PEGS . 2015

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5. Population pharmacokinetics of therapeutic monoclonal antibodies: Examples and estimation method performance differences. [D] . Dirks, Nathanael Le. 2010

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6. Population pharmacokinetics of the humanised monoclonal antibody HuHMFG1 (AS1402) derived from a phase I study on breast cancer [O] . B Royer, W Yin, M Pegram, 2010

机译：人源化单克隆抗体HuHMFG1（AS1402）的群体药代动力学来自于乳腺癌的I期研究
7. Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer [O] . Royer, B, Yin, W, Pegram, M, 2010

机译：人源化单克隆抗体HuHMFG1（AS1402）的群体药代动力学，来自于乳腺癌的I期研究
8. Monoclonal Antibodies and Cancer. Studies on the Use of Monoclonal Antibodies for Imaging and Therapy of Cancer, with Special Emphasis on Ovarian Carcinoma [R] . Haisma, H. J. 1987

机译：单克隆抗体和癌症。单克隆抗体在癌症成像和治疗中的应用研究，特别强调卵巢癌

Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer

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