Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array

D M Kweekel; N F Antonini; J W R Nortier; C J A Punt; H Gelderblom; H-J Guchelaar

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Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array

机译：使用DNA修复阵列鉴定与奥沙利铂功效和毒性有关的新候选基因的探索性研究

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Purpose:To identify new polymorphisms (single nucleotide polymorphisms, SNPs) in DNA repair pathways that are associated with efficacy and toxicity in patients receiving oxaliplatin and capecitabine for advanced colorectal cancer (ACC).

机译：目的：确定在DNA修复途径中新的多态性（单核苷酸多态性，SNP）与接受奥沙利铂和卡培他滨治疗晚期大肠癌（ACC）患者的疗效和毒性有关。

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《British Journal of Cancer》 |2009年第2期|共6页
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D M Kweekel; N F Antonini; J W R Nortier; C J A Punt; H Gelderblom; H-J Guchelaar;
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中图分类肿瘤学;
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1. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. [J] . Lan Q, Zhang L, Shen M, Carcinogenesis . 2009,第1期

机译：候选基因的大规模评估确定了DNA修复与基因组维护与苯血液毒性发展之间的关联。
2. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and developmentn of benzene hematotoxicity [J] . Carcinogenesis . 2009,第1期

机译：候选基因的大规模评估确定了DNA修复与基因组维持与苯血液毒性发展之间的关联
3. A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. [J] . Depondt C, Godard P, Espel RS, European journal of neurology: the official journal of the European Federation of Neurological Societies . 2011,第9期

机译：一项抗癫痫药耐受性和功效的候选基因研究确定了CYP2C9变体与苯妥英钠毒性相关。
4. INTERACTIONS OF OXALIPLATIN AND CARBOPLATIN WITH DNA BUILDING BLOCKS AS STUDIED IN THE GAS PHASE: A COMBINED EXPERIMENTAL AND THEORETICAL STUDY [C] . Jean-Yves Salpin, Maria Elisa Crestoni, Davide Corinti, International Mass Spectrometry Conference . 2018

机译：在气相中研究的DNA构建块与DNA构建块的相互作用：一种实验与理论研究
5. Characterization of an apurinic /apyrimidinic endonuclease heterozygous knockout mouse: Identifying nutrient-gene and gene-environment interactions on DNA repair. [D] . Raffoul, Julian John. 2004

机译：apurinic / apyrimidinic核酸内切酶杂合敲除小鼠的特征：鉴定DNA修复中的营养基因和基因环境相互作用。
6. Regarding: ‘Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array [O] . J Pander, H Gelderblom, T van der Straaten, 2010

机译：关于：利用DNA修复阵列鉴定与奥沙利铂功效和毒性有关的新候选基因的探索性研究
7. Regarding: ‘Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array' [O] . Pander, J, Gelderblom, H, van der Straaten, T, 2010

机译：关于：“利用DNA修复阵列鉴定与奥沙利铂功效和毒性有关的新候选基因的探索性研究”

Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array

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