Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

M A Gonzalez; S Biswas; L Clifton; P G Corrie

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Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

机译：输注5-氟尿嘧啶，亚叶酸和链佐星治疗神经内分泌肿瘤

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A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.

机译：迄今为止，尚未建立用于转移性神经内分泌肿瘤（NETs）的标准化，有效的全身疗法。我们回顾了15例无法手术的转移性NET的治疗，这些患者已通过5-氟尿嘧啶，亚叶酸和链脲佐菌素输注的联合化疗方案进行了系统治疗。总体客观反应率为53％，耐受性极好。

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《British Journal of Cancer》 |2003年第3期|共2页
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M A Gonzalez; S Biswas; L Clifton; P G Corrie;
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中图分类肿瘤学;
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1. A randomised phase III intergroup trial comparing high-dose infusional 5-fluorouracil with or without folinic acid with standard bolus 5-fluorouracil/folinic acid in the adjuvant treatment of stage III colon cancer: The Pan-European Trial in Adjuvant Colon Cancer 2 study [J] . K?hneC.-H., BedenneL., CarratoA., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2013,第8期

机译：一项III期随机对照试验，比较了大剂量输注5-氟尿嘧啶或不加亚叶酸与标准推注5-氟尿嘧啶/亚叶酸在III期结肠癌辅助治疗中的应用：泛欧辅助性结肠癌试验2
2. Comparison of a 48-Hour Infusion of 5-Fluorouracil without Folinic Acid with 24-Hour Folinic Acid/5-Fluorouracil in Patients with Metastatic Colorectal Cancer Refractory to Bolus Folinic Acid/5-Fluorouracil. A Prospective Cohort Study. [J] . Moehler M, Gutzler F, Steinmann S, Chemotherapy: International Journal of Experimental and Clinical Chemotherapy . 2003,第1a2期

机译：转移性结直肠癌对顽固性亚叶酸/ 5-氟尿嘧啶难治性患者中48小时输注不含亚叶酸的5-氟尿嘧啶与24小时亚叶酸/ 5-氟尿嘧啶的比较。前瞻性队列研究。
3. Hepatic arterial infusion (HAI). Comparison of 5-fluorouracil, folinic acid, interferon alpha-2b and degradable starch microspheres versus 5-fluorouracil and folinic acid in patients with non-resectable colorectal liver metastases. [J] . Pohlen U, Rieger H, Mansmann U, Anticancer Research: International Journal of Cancer Research and Treatment . 2006,第5B期

机译：肝动脉输注（HAI）。不能切除的结直肠肝转移患者中5-氟尿嘧啶，亚叶酸，干扰素α-2b和可降解淀粉微球与5-氟尿嘧啶和亚叶酸的比较。
4. Comparing Administration Route in Rats with Streptozocin-Induced Diabetes and Inhibition of Myoblast Growth of Vanadium V(III), V(IV), and V(V) Dipicolinic Acid Complexes [C] . Gail R. Willsky, Michael E. Godzalla, Paul J. Kostyniak, International Symposium on Chemistry and Biological Chemistry of Vanadium . 2007

机译：比较在糖尿病诱导的糖尿病大鼠大鼠中的给药途径和钒的肌细胞生长V（III），V（IV）和V（V）二聚溶胶酸配合物
5. Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification [D] . Takahashi Daigoro, 高橋大五郎 2019

机译：用多光谱成像分析胰腺神经内分泌肿瘤的肿瘤免疫微环境表明符合WHO 2017分类的不同亚群特征
6. Treatment of neuroendocrine tumours with infusional 5-fluorouracil folinic acid and streptozocin [O] . M A Gonzalez, S Biswas, L Clifton, 2003

机译：输注5-氟尿嘧啶亚叶酸和链佐星治疗神经内分泌肿瘤
7. Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin [O] . Gonzalez, M A, Biswas, S, Clifton, L, 2003

机译：输注5-氟尿嘧啶，亚叶酸和链佐星治疗神经内分泌肿瘤

Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

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