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首页> 外文期刊>British Journal of Cancer >Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female SD-rats
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Effects of vitamin A and E supplementation to diets containing two different fat levels on methylnitrosourea-induced mammary carcinogenesis in female SD-rats

机译:补充两种不同脂肪水平的饮食中维生素A和E对甲基亚硝基脲诱导的雌性SD大鼠乳腺致癌作用的影响

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The aim of this study was to elucidate the effects of dietary vitamin A and E supplementation on tumorigenesis in correlation to the fat content of the respective diet in an animal model. One hundred and twenty female SD rats were initiated intravenously with 25 mg MNU kg-1 on day 50 of life. For a period of 6 months, beginning after the day of initiation, all animals received a semisynthetic diet containing 25% or 45% of the energy as fat, supplemented either with a 10-fold higher amount of naturally occurring vitamins A and E than in rat standard diets or, with a normal level of these vitamins. The experiment showed: (1) Vitamin A and E supplementation showed no significant chemopreventive effect against mammary tumour development. (2) This result was independent from the supplied fat level of the respective diet. (3) The fat content per se did not significantly influence mammary tumorigenesis.
机译:这项研究的目的是在动物模型中阐明饮食中维生素A和E的补充对肿瘤发生的影响。在生命的第50天,用25 mg MNU kg-1静脉内注射120只雌性SD大鼠。在开始使用后的6个月内,所有动物均接受半合成饮食,其中包含25%或45%的能量为脂肪,并补充了天然维生素A和E的10倍。大鼠的标准饮食或这些维生素的正常水平。实验表明:(1)补充维生素A和E对乳腺癌的发展没有明显的化学预防作用。 (2)该结果与各自饮食中提供的脂肪水平无关。 (3)本身的脂肪含量没有显着影响乳腺肿瘤的发生。

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