Gd-complexes of DTPA-bis(amide) Conjugates of Phosphonated Tranexamic Esters as MRI Contrast Agents

摘要

The syntheses of DTPA-bis(amide) conjugates of phosphonated cyclohexane moieties (5a-d) and their Gd(III) complexes of the type [Gd(L)(H2O)]·nH2O (6a-d; L = 5a-d) are described. All new compounds have been characterized by microanalysis and spectroscopic techniques. High r1 relaxivities of aqueous solutions of 6a-d are observed to be in the range of 10.7-18.3 mM−1sec−1, which compare much better than that of Omniscan® (r1 = 3.90 mM−1sec−1).