Association ofCILP2andACEGene Polymorphisms with Cardiovascular Risk Factors in Slovak Midlife Women

摘要

The aim of this study is to assess the association of two polymorphisms, the cartilage intermediate layer protein 2 (CILP2) G/T and angiotensin converting enzyme (ACE) I/D, with blood pressure and anthropometrical and biochemical parameters related to the development of cardiovascular disease. The entire study sample comprised 341 women ranging in age from 39 to 65 years. TheCILP2genotypes were determined by PCR-RFLP and theACEgenotypes by PCR. The Bonferroni pairwise comparisons showed the effect of theCILP2genotype on high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), apoB-to-apoA1 ratio, the total cholesterol (TC)-to-HDL-C ratio, non-HDL-C, and the LDL-C-to-HDL-C ratio (P<0.05). Here, higher mean levels of HDL-C and lower mean levels of the remaining above mentioned lipid parameters were registered in the GT/TT genotype carriers than in GG carriers. Statistically significant association was identified between theACEgenotype and the following parameters: TC, LDL-C, and non-HDL-C (P<0.05). The II genotype can lower serum level of TC (B=0.40), LDL-C (B=0.37), and non-HDL-C levels. The results of this study suggest that the minor T allele ofCILP2gene and I allele ofACEgene have a protective effect against elevated serum lipid and lipoprotein levels.