Serum markers of Iron metabolism in individuals with diabetes mellitus from a population with high prevalence of anaemia

摘要

The alteration in iron metabolism in diabetes was found to be mediated by cytokines. The cytokines also increase the hepatic synthesis of hepcidin. Hepcidin in turn inhibits release of iron from reticuloendothelial cells which cause a relative rise in ferritin in these cells .This rise in ferritin at the cellular stores is reflected in the rise in serum ferritin. The mild increase in CRP (hsCRP)is also explained by increase in cytokines.