EFFECTS OF BAICALIN ON INFLAMMATORY MEDIATORS AND PANCREATIC ACINAR CELL APOPTOSIS IN RATS WITH SEVER ACUTE PANCREATITIS

摘要

Background: To investigate the effects of Baicalin and Octreotide on inflammatory mediators and pancreatic acinar cells apoptosis of rats with severe acute pancreatitis (SAP).Methods: SD rats were randomly divided into sham operated group (I group), model control group (II group), Baicalin treated group (III group) and Octreotide treated group (IV group). Each group was also divided into subgroup of 3, 6 and 12 h (n=15). The mortality rate, ascites / body weight ratio as well as the level of endotoxin, NO and ET-1 in blood was measured. The pathological severity score of pancreas, apoptotic indexes, and expression levels of Bax and Bcl-2 proteins in each group were investigated.Results: The survival rate of III and IV group has a significant difference compared with II group (P_12h3, 6h6h3h, 6h3hConclusions: Compared with Octreotide in the treatment of SAP, the protective mechanisms of Baicalin include reducing the excessive inflammatory mediators’ release, inducing the pancreatic acinar cells apoptosis.