Effect of Intravenous Albumin Administration on HEMATOM Volume after Hemorrhagic Stroke

摘要

BackgroundandObjective:Theaimofthisstudywastoevaluatetheeffectofalbumininhematomvolumeafterhemorrhagicstroke.SubjectsandMethods:Thestudywasconductedinarandomizedclinicaltrial;patientswithhemorrhagicstrokein24hoursofonsetwereincluded.Patientsweredividedintotwogroups,thefirstgroupwastreatedwithintravenousalbumin(1g/Kg)andsecondgrouptreatedsimilarlywithnormalsalineasplacebo.Hematomvolumewascalculatedbeforeandattheendoftreatment.AnalyzesofdatawasmadeusingChisquareandT-Test.LevelofdisabilityatbaselineandendoftreatmentwerecomparedwiththeNIHSS.Results:From61patientswerestudied;31patientstreatedwithalbuminand30patientsreceivedplacebo.Patientswerematchedforage,sexandriskfactors.Meanchangesinhematomavolumeinthecontrolgroupwas2.88(SD=1.42)mlandintheplacebogroupwas1.75(SD=1.27)ml.Thedifferencesobservedbetweenthetwogroupswasstatisticallysignificant(P=0.002).InthecontrolgroupthemeanchangeinNIHSSwas2.83(SD=1.26)andthemedianchangewas3andinthecasegroupthemeanchangeinNIHSSwas1.59(SD=1.21)andthemedianchangeswas1.Thedifferencebetweenthetwogroupswasstatisticallysignificant(P0.001).Conclusion:Theresultsofthisstudyshowedthattheuseofintravenousalbumininpatientswithhemorrhagicstrokecanfurtherreducingthesizeofthehematomaandthepatient#039;sneurologicaldeficitswithpossiblebetteroutcomes.